• Thu. Jan 20th, 2022

Vitamin B6 (Pyridoxal Phosphate – PLP) – Functions – Deficiency of Vitamin B6

Vitamin b6 so these three compounds are paradox in pyridoxal and pyridoxamine and the main difference between these three compounds is the functional group which is attached onto this aromatic ring which you can see here so the functional groups attached are going to be slightly different and these three compounds here are precursors of something which is known as pyridoxal phosphate the pyridoxal phosphate is the active form of vitamin b6 and this act as a coenzyme or a cofactor for many enzymes in the human body so without this pyridoxal phosphate these enzymes which catalyze certain reactions they wouldn’t be able to function so it’s especially common in reactions involving amino acids and I’ve made a note here that paradox seen and paradox so you’ll find them in animal products and pyridoxamine you’ll find from plant products so let’s talk about the functions of this pyridoxal phosphate so a variety of enzymes known as transaminases they require PRP to transfer amine groups between amino acids so without this.

You wouldn’t be able to convert certain amino acids into different amino acids pyridoxal phosphate is involved in the biosynthesis of five neurotransmitters and those are serotonin dopamine Epinephrine norepinephrine and gaba. PRP is also involved in the synthesis of histamine and the enzyme which breaks down glycogen which is known as glycogen phosphorylase that requires pyridoxal phosphate to function pyridoxal phosphate is also required for the enzymes which synthesize and break down sphingolipids which is a type of lipid or fat and the pyridoxal phosphate binds on – – sites on hemoglobin to enhance the oxygen binding of hemoglobin now these are just a few of the functions  ere are a lot more but I’ve just focused on these six ones here so let’s talk about these sources of vitamin b6.

It’s a high amounts in beef pork turkey bananas potatoes and chickpeas and the recommended daily amount for vitamin b6 is 1.3 milligrams per day and that’s for adults between 19 to 50 years old so some symptoms of the deficiency of vitamin b6 it’s a seborrhoeic dermatitis which is this diagram here you can see these rashes on the skin it also can contribute to angular colitis which is you can see on the corner of the of the mouth there’s some inflammation here this image is actually a very mild case of angular colitis but it is a contributing factor to this inflammatory disease here it also contributes to chronic conjunctivitis which you can see from this diagram here and it also is involved in a trophic glossitis with ulceration so that’s inflammation of the tongue another symptom of the deficiency of vitamin b6 rushes on the skin and some neurological symptoms you can find from a deficiency of vitamin b6 are symptoms such as drowsiness confusion and nerve damage.